Clinico-Pathological Studies on Helicobacter pylori Infection in Albino Rats

Ghobashi, Essaa AA; Abd-Ellatieffb, Hoda A; Goda, Wael M; Hamada, Rania; Abou-Rawash, Abdel-Rahman; Hassan, Shahinaz M. H.

doi:10.21608/djvs.2022.146381.1082

Clinico-Pathological Studies on Helicobacter pylori Infection in Albino Rats

Document Type : Original Article

Authors

¹ Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

² Animal Health Research Institute (AHRI) Agricultur Research Center (ARC), Alexanderia regional Lab., Alexanderia, Egypt.

10.21608/djvs.2022.146381.1082

Abstract

Helicobacter pylori (H. pylori) is known to be the most common agent in peptic ulcers and chronic gastritis. The goal of this study was to investigate how H. pylori infection affect several hematological and biochemical parameters. To achieve this goal, thirty albino male rats were divided into three groups for challenge with H. pylori Ag. Two groups were daily fed on H. pylori suspensions in food and water, whereas the third group was kept as a control group. Serum iron, ferritin, copper (Cu), zinc (Zn), magnesium (Mg), lipid profile, SGPT (ALT), SGOT (AST), and full blood picture were all measured at day 90 (the end of the experiment). The findings demonstrated that H. pylori stool Ag was present in the feces of infected rat groups and was elevated throughout the trial. Antibodies against H. pylori have increased in serum. Hematological and biochemical markers, particularly iron and ferritin, as well as hemoglobin and leukocytes, were all negatively affected. In addition, all signs of gastric inflammation were demonstrated among the infected groups. Overall, after exposure to H. pylori infected food and water, numerous haematological parameters were disturbed and seriously impacted various organs.

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