Exploring the Potential of Saussurea Costus Bioactive Compounds in Targeting MMP2/9 for Innovative Breast Cancer Therapy: An In-Silico Perspective

Document Type : Original Article

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1 Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522

2 Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt

Abstract

Cancer remains a significant challenge for global public health, accounting for nearly one in six deaths worldwide. Even with remarkable progress in cancer treatment in recent decades, the intricate nature of cancer cells, which facilitates swift mutation processes and reduces the effectiveness of standard chemotherapy, continues to fuel research into alternative and complementary therapy treatments.
Molecular docking studies further confirmed that bioactive compounds in Saussurea costus (COS), such as LTS0119846, LTS0188050, LTS0102500, LTS0147418, and LTS0253995, interact with key metastasis-related proteins, including matrix metalloproteinases (MMP-2 and MMP-9), which contribute to its anti-metastatic effects. These findings suggest that COS bioactive compounds may be promising anticancer agents of natural origin. This study highlights the potential of COS as a natural therapeutic agent in cancer treatment, offering a multi-targeted approach that addresses both tumor progression and metastasis. The integration of COS into chemotherapy regimens could improve treatment outcomes. Future studies should focus on validating these results in vivo, clinical trials, and bioavailability optimization to facilitate the translation of COS-based therapies into clinical practice.

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