Document Type : Original Article
Authors
1
Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour , Egypt
2
Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt
3
Department of Biochemistry, Animal Health Research Institute (AHRI), Damanhour Branch, Agriculture Research Centre (ARC), Damanhour , Egypt
4
Molecular Biology, Molecular Biology Unit, Medical Technology Centre, Medical Research Institute, Alexandria University, Egypt
10.21608/djvs.2024.302055.1133
Abstract
mTOR pathway is involved in the aging process but the understanding of all mechanisms remains needs more extensive research. In the current study, we investigated the molecular docking interactions of catechin, caffeic acid, carvacrol, diosgenin, eugenol, and rutin against mTOR. Results indicated the ability of investigated natural bioactive compounds to interact with mTOR with binding energy of -5.68, -4.87, -4.57, -7.34, -7.34, -9.72 kcal/mol. More in vitro and in vivo experiments are extremely needed to understand the mechanistic role of these natural bioactive compounds to hinder mTOR’s aging process participation.
mTOR pathway is involved in the aging process but the understanding of all mechanisms remains needs more extensive research. In the current study, we investigated the molecular docking interactions of catechin, caffeic acid, carvacrol, diosgenin, eugenol, and rutin against mTOR. Results indicated the ability of investigated natural bioactive compounds to interact with mTOR with binding energy of -5.68, -4.87, -4.57, -7.34, -7.34, -9.72 kcal/mol. More in vitro and in vivo experiments are extremely needed to understand the mechanistic role of these natural bioactive compounds to hinder mTOR’s aging process participation.
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