Biochemical alterations associated with experimentally induced breast cancer in rats

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Egypt

2 Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt

3 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt

4 Department of Animal Husbandry and Wealth Development, Faculty of Veterinary Medicine, Damanhour University, Egypt

Abstract

This study was conducted to demonstrate the preventive graviola effect
on breast cancer induced by 7,12-dimethylbenz [a] anthracene (DMBA) in
fifty female rats distributed into four groups. Group I: Control group
injected orally by physiological saline, group II: DMBA induced-breast
cancer, injected orally a single dose of DMBA (50mg/kg) diluted in
sesame oil (1 ml), group III: Graviola 200 mg/kg two times per week
given orally by gavage from the first day of the experiment till the end plus
a single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given
orally at age of 57 days and group IV: rats treated with single dose of
DMBA (50mg/kg) diluted in sesame oil (1mL) given orally plus graviola
200 mg/kg two times weekly both at age of 57 days till the end. After 30w
the animals were anaesthetized to collect blood samples to determine the
hepatic and renal protection of graviola. Treatment with graviola
significantly (p< 0.05) reduced ALT activity and creatinine level. We can
conclude that graviola mitigated hepatic and kidney functions.

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