The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency

Kassem, Mostafa; Nasr, Mohamed; Sadik, Kadry; Belal, Shrouk

doi:10.21608/djvs.2019.62120

The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency

Document Type : Original Article

Authors

¹ Surgery Department, Faculty of Veterinary Medicine, Alexandria University

² Animal Medicine Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt

³ Biochemistry Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt

⁴ Food Safety and Hygiene Laboratory, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt

10.21608/djvs.2019.62120

Abstract

The present study was aimed to evaluate anesthetic properties, clinic-physiological and hemato-biochemical effects of propofol alone, thiopental alone or propofol/thiopental mixture in dogs with experimental liver insufficiency. For this purpose, 9 apparently healthy male dogs exposure to electrocauterization to induce liver insufficiency model. The dogs were randomly divided into three groups; each group consists of three dogs. All dogs were premedicated with Xylazine Hcl (1mg/kg bwt/i.m). The induction of general anesthesia was done via i/v injection of 6 mg/kg bwt Propofol (group A); 5mg/kg bwt Thiopental (group B) and 3 mg/kg Propofol + 2.5 mg/kg Thiopental mixture (group C). Blood samples were collected from the three groups at15mins before anesthesia induction then at 15, 30 and 45 minutes after treatments for both clinico-physiological and hemato-biochemical evaluations. A mild alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction in all groups, but it still safe induce general anesthesia in dogs affected with liver insufficiency. However, Propofol /Thiopental mixture was induced a rapid, smooth induction and a longer duration of anesthesia with complete muscle relaxation which is suitable for all most surgical operations.

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